AOD-9604 Frag Stack

The AOD-9604 Frag Stack combines AOD-9604''s direct fat-burning action with Ipamorelin''s GH pulse support, creating a two-part protocol that attacks fat during the fasted morning window and optimizes GH output during nocturnal sleep — the two periods of highest natural fat metabolism. AOD-9604 (also known as Fragment 176-191) is a modified fragment of human growth hormone''s C-terminus that retains GH''s lipolytic (fat-breaking) activity without its growth-promoting, insulin-sensitizing, or IGF-1-raising effects. This makes it unusually clean: it specifically mobilizes stored fat for energy through fat cell receptor activation without the side effects associated with full GH or GH secretagogues. It was studied in human clinical trials by Metabolic Pharmaceuticals and showed statistically significant fat reduction with minimal adverse events. Ipamorelin is dosed before sleep to amplify the natural nocturnal GH pulse — the body''s primary growth hormone secretion window. This GH pulse drives fat metabolism during sleep and supports lean tissue preservation and growth. Because Ipamorelin is highly selective (no cortisol, no appetite stimulation), it is the cleanest GHRP choice to pair with a pure fat loss compound. The timing split is intentional: AOD-9604 in the morning fasted state capitalizes on the low-insulin environment for maximum lipolysis, while Ipamorelin at night amplifies the nocturnal GH pulse. Together they target fat loss across both the AM and PM metabolic windows.