TB-500
Thymosin Beta-4 / TB4 / Tβ4
TB-500 is a synthetic fragment of Thymosin Beta-4 (TB4), a naturally occurring 43-amino acid protein found in virtually all human and animal cells that plays a critical role in tissue repair and regeneration. Originally studied extensively in equine veterinary medicine, it has become one of the most widely researched recovery peptides in clinical and preclinical settings. Its primary applications center on wound healing, reduction of inflammation, and promotion of cellular migration to injury sites.
Mechanism of Action
Synthetic analog of thymosin beta-4. Promotes cell migration by sequestering G-actin and upregulating actin polymerization. Reduces inflammation via NF-kB modulation, promotes stem cell differentiation, and accelerates wound healing and tissue repair.
Research Protocols
For research purposes only. Not medical advice.
Research protocols use 2-5mg twice weekly for the loading phase (4-6 weeks), then 2mg weekly for maintenance. Subcutaneous injection. Some protocols use intramuscular injection near injury site.
Research Notes
Clinical Research Status
TB-500 remains investigational with no FDA approval for human use, though Thymosin Beta-4 has been studied in human clinical trials for wound healing and corneal repair. RegeneRx Biopharmaceuticals conducted Phase 2 trials on the full-length TB4 molecule for dermal and ocular indications. The synthetic fragment TB-500 (amino acids 17-23 of TB4) is widely available through research chemical suppliers.
Key Published Findings
Animal studies demonstrate significant acceleration of wound closure, hair regrowth, and cardiac tissue repair following ischemic injury. TB4 upregulates actin polymerization and promotes cellular migration, angiogenesis, and extracellular matrix deposition. Research in rodent models shows reduced scar formation and improved functional recovery from muscle tears and ligament injuries.
Safety Profile
No serious adverse events were reported in human clinical trials of Thymosin Beta-4 at therapeutic doses. Common anecdotal reports include transient head rush, lethargy at initiation, and mild irritation at injection sites. The peptide is banned by WADA under section S2 (Peptide Hormones, Growth Factors, Related Substances).
Drug Interactions & Contraindications
No well-documented drug interactions exist due to limited human clinical data. Theoretical concern exists regarding use in individuals with active cancer, as TB4's pro-angiogenic and cell migration properties could theoretically promote tumor progression. Should be avoided in individuals with known malignancies pending further safety data.
Comparison to Related Compounds
TB-500 is frequently stacked with BPC-157 in recovery protocols, with the two peptides thought to work synergistically through complementary mechanisms (systemic vs. local repair). Unlike BPC-157 which acts primarily through growth factor modulation, TB-500 works via actin sequestration and cytoskeletal reorganization. Full-length Thymosin Beta-4 is more expensive and less stable than the TB-500 fragment.
Community Observations
Most commonly dosed at 2-5mg injected subcutaneously 1-2 times per week during a loading phase, then reduced to weekly maintenance. Users frequently report improved recovery from musculoskeletal injuries within 2-4 weeks of initiation. The peptide is popular among athletes and those recovering from surgical procedures or chronic tendon injuries.
Half-Life
~6-8 hours
Reconstitution
Bacteriostatic water (BAC)
Storage
Lyophilized
Refrigerate 2-8C up to 18 months.
Reconstituted
Refrigerate 2-8C. Use within 14 days.
US Legal Status
Also Known As
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