REGULATORYRFK Jr.: 14 peptides returning to Category 1 — FDA advisory committee July 2026TRENDINGHexarelin: ↑↑ Surging ��� Trends score 100 as of May 2026UPDATESemaglutide and tirzepatide compounding ended — shortage resolved Feb/May 2025REGULATORYBPC-157, TB-500, thymosin alpha-1, CJC-1295, ipamorelin: expected Category 1 reclassification pendingEVENTpep-talk con ��� First US Peptide Convention · August 2026 · Anaheim CAFDAFDA advisory committee meetings scheduled: late July 2026REGULATORYRFK Jr.: 14 peptides returning to Category 1 — FDA advisory committee July 2026TRENDINGHexarelin: ↑↑ Surging ��� Trends score 100 as of May 2026UPDATESemaglutide and tirzepatide compounding ended — shortage resolved Feb/May 2025REGULATORYBPC-157, TB-500, thymosin alpha-1, CJC-1295, ipamorelin: expected Category 1 reclassification pendingEVENTpep-talk con ��� First US Peptide Convention · August 2026 · Anaheim CAFDAFDA advisory committee meetings scheduled: late July 2026

For research purposes only. Full disclaimer →

Peptide Library

HMG

Human Menopausal Gonadotropin / Menopur / Pergonal

Sexual Health

Human Menopausal Gonadotropin (HMG) is a urinary-derived preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in approximately equal proportions, extracted and purified from the urine of postmenopausal women. It is FDA-approved for the treatment of infertility in both men and women, stimulating follicular development in women and spermatogenesis in men. Brand names include Menopur and Pergonal, and it remains a cornerstone of assisted reproductive technology.

Mechanism of Action

Combination of FSH and LH extracted from post-menopausal urine. Directly stimulates ovarian follicular development (FSH component) and supports ovulation and corpus luteum function (LH component). Used in assisted reproduction protocols.

Research Protocols

For research purposes only. Not medical advice.

Fertility protocols use 75-150 IU daily via intramuscular injection, adjusted based on ovarian response monitoring. Male protocols for spermatogenesis use 75-150 IU 2-3 times weekly with HCG.

Research Notes

Clinical Research Status

HMG has been used in fertility medicine since the 1960s and holds FDA approval for ovulation induction in women with anovulatory infertility and for spermatogenesis stimulation in men with hypogonadotropic hypogonadism. Highly purified urinary HMG (Menopur) and recombinant alternatives (Gonal-F for FSH, Luveris for LH) provide different formulation options. Ongoing research compares urinary-derived versus recombinant gonadotropins for IVF outcomes.

Key Published Findings

Clinical trials demonstrate that HMG protocols produce equivalent or slightly superior IVF outcomes compared to recombinant FSH alone, possibly due to the LH component's contribution to follicular steroidogenesis. In male infertility, HMG combined with HCG can restore spermatogenesis in men with gonadotropin deficiency, with sperm appearing in ejaculate typically within 6-18 months. The LH activity in HMG supports theca cell androgen production necessary for optimal follicular development.

Safety Profile

Ovarian hyperstimulation syndrome (OHSS) is the most significant risk, ranging from mild (abdominal bloating) to severe (ascites, thromboembolism), requiring careful ultrasound and estradiol monitoring during stimulation cycles. Multiple pregnancy rates are elevated (15-25% in IUI cycles) due to multi-follicular development. In male patients, adverse effects are generally limited to gynecomastia and acne from increased testosterone and estrogen production.

Comparison to Related Compounds

Unlike recombinant FSH (follitropin alfa/beta), HMG contains both FSH and LH activity, providing a more complete gonadotropin stimulus. Compared to HCG which mimics only LH, HMG provides direct FSH stimulation critical for Sertoli cell function and spermatogenesis initiation. Highly purified HMG (Menopur) contains LH activity primarily from HCG co-purified from urine rather than true LH, though biological activity is equivalent.

Community Observations

Fertility specialists often debate the clinical significance of the LH component in HMG versus pure FSH protocols, with some evidence favoring HMG in specific patient populations (older women, poor responders). In male fertility protocols, HMG is typically added to HCG after initial testosterone normalization to specifically target spermatogenesis. Cost considerations remain relevant as urinary-derived preparations are generally less expensive than recombinant alternatives.

Half-Life

~24-48 hours

Reconstitution

Sterile diluent provided with kit

Storage

Lyophilized

Refrigerate 2-8C.

Reconstituted

Use immediately after reconstitution.

US Legal Status

FDA-approved (Rx only)

Also Known As

Human Menopausal GonadotropinMenopurPergonal

PeptideVault provides research-based summaries for informational purposes only. We do not host, distribute, or endorse vendor documentation. All certificates of analysis, GMP certificates, and vendor communications must be requested and verified directly by the buyer. Nothing on this platform constitutes legal, medical, or professional advice. Users are solely responsible for verifying vendor credentials and ensuring compliance with all applicable local, state, and federal laws before purchasing any research chemicals. Use of this platform constitutes acceptance of full personal responsibility.

Read full disclaimer