REGULATORYRFK Jr.: 14 peptides returning to Category 1 — FDA advisory committee July 2026UPDATESemaglutide and tirzepatide compounding ended — shortage resolved Feb/May 2025REGULATORYBPC-157, TB-500, thymosin alpha-1, CJC-1295, ipamorelin: expected Category 1 reclassification pendingFDAFDA advisory committee meetings scheduled: late July 2026RESEARCHTranslational Health Research Into Vascular and Neurocognitive Effects of Weight Loss [NCT07592546]RESEARCHA Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) [NCT07165028]RESEARCHTirzepatide in the Treatment of Endometrial Cancer [NCT07605247]RESEARCHA Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan [NCT06635057]RESEARCHA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide [NCT06897475]RESEARCHA Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature [NCT06382155]RESEARCHMetabolic Effects of Angiotensin-(1-7) [NCT02646475]RESEARCHMulti-Site Trial of Tirzepatide for Smoking Cessation [NCT07602699]RESEARCHEvaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder [NCT06651177]NEWSOorja, run by Acceleron veterans, launches to make new fibrosis drugsREGULATORYRFK Jr.: 14 peptides returning to Category 1 — FDA advisory committee July 2026UPDATESemaglutide and tirzepatide compounding ended — shortage resolved Feb/May 2025REGULATORYBPC-157, TB-500, thymosin alpha-1, CJC-1295, ipamorelin: expected Category 1 reclassification pendingFDAFDA advisory committee meetings scheduled: late July 2026RESEARCHTranslational Health Research Into Vascular and Neurocognitive Effects of Weight Loss [NCT07592546]RESEARCHA Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) [NCT07165028]RESEARCHTirzepatide in the Treatment of Endometrial Cancer [NCT07605247]RESEARCHA Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan [NCT06635057]RESEARCHA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide [NCT06897475]RESEARCHA Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature [NCT06382155]RESEARCHMetabolic Effects of Angiotensin-(1-7) [NCT02646475]RESEARCHMulti-Site Trial of Tirzepatide for Smoking Cessation [NCT07602699]RESEARCHEvaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder [NCT06651177]NEWSOorja, run by Acceleron veterans, launches to make new fibrosis drugs

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Peptide Library

CJC-1295 (with DAC)

CJC-1295 DAC / Drug Affinity Complex CJC-1295

Growth Hormone Secretagogues

CJC-1295 with DAC (Drug Affinity Complex) is a long-acting synthetic GHRH analog that incorporates a maleimidopropionic acid linker enabling covalent binding to serum albumin, extending its half-life to 6-8 days. Developed by ConjuChem Biotechnologies, it produces sustained elevation of growth hormone and IGF-1 levels from a single weekly injection. It is primarily researched for growth hormone deficiency, muscle wasting, and age-related GH decline.

Mechanism of Action

Modified GHRH analog conjugated to a Drug Affinity Complex (DAC) that binds serum albumin, dramatically extending half-life. Produces sustained elevation of GH and IGF-1 levels rather than pulsatile release. Continuously stimulates GHRH receptors.

Research Protocols

For research purposes only. Not medical advice.

Research protocols use 1-2mg once or twice weekly via subcutaneous injection. The long half-life means GH elevation is sustained, not pulsatile. Less frequent dosing but different pharmacodynamic profile than no-DAC version.

Research Notes

Clinical Research Status

CJC-1295 with DAC reached Phase 2 clinical trials before development was discontinued following a participant death attributed to a myocardial infarction (causality was debated). Published trials demonstrated significant and sustained increases in GH and IGF-1 with weekly or biweekly dosing. The compound remains available through research suppliers despite the halted clinical program.

Key Published Findings

A single 30-60mcg/kg injection produced sustained GH elevation for 6+ days and IGF-1 increases of 1.5-3x baseline lasting up to 2 weeks. The GHRH analog demonstrated dose-proportional pharmacokinetics with predictable IGF-1 responses. Studies showed increases in lean body mass and reductions in visceral fat with repeated administration.

Safety Profile

The sustained GH elevation raises theoretical concerns about prolonged IGF-1 exposure compared to pulsatile protocols. Common side effects include injection site reactions, water retention, paresthesias, and headache. The extended half-life means side effects may persist for days rather than hours, making dose titration more challenging.

Drug Interactions & Contraindications

Same contraindications as the no-DAC variant apply, with additional concern regarding the inability to quickly discontinue effects due to the long half-life. Not recommended in combination with exogenous GH as this may cause excessive IGF-1 elevation. Contraindicated in diabetic patients due to GH's insulin-antagonistic effects at sustained high levels.

Comparison to Related Compounds

The DAC variant provides convenience of weekly dosing but sacrifices the physiological pulsatile GH pattern that the no-DAC version produces. Most researchers now prefer the no-DAC version combined with a GHRP for a more natural GH profile with better safety margins. The sustained elevation from DAC may increase risk of side effects associated with chronic GH excess (joint pain, insulin resistance, fluid retention).

Community Observations

Typically dosed at 1-2mg once or twice weekly via subcutaneous injection. Less popular than the no-DAC variant among experienced users due to concerns about blunted GH pulsatility and potential for desensitization. Some users combine it with GHRPs on non-injection days to maintain pulsatile stimulation alongside the baseline elevation.

Half Life

~6-8 days

Reconstitution

Bacteriostatic water (BAC)

Storage

Lyophilized

Refrigerate 2-8C up to 24 months.

Reconstituted

Refrigerate 2-8C. Use within 30 days.

US Legal Status

Research chemical (not FDA-approved)

Also Known As

CJC-1295 DACDrug Affinity Complex CJC-1295

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