REGULATORYRFK Jr.: 14 peptides returning to Category 1 — FDA advisory committee July 2026UPDATESemaglutide and tirzepatide compounding ended — shortage resolved Feb/May 2025REGULATORYBPC-157, TB-500, thymosin alpha-1, CJC-1295, ipamorelin: expected Category 1 reclassification pendingFDAFDA advisory committee meetings scheduled: late July 2026RESEARCHA Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature [NCT06382155]RESEARCHMetabolic Effects of Angiotensin-(1-7) [NCT02646475]RESEARCHEvaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder [NCT06651177]RESEARCHMulti-Site Trial of Tirzepatide for Smoking Cessation [NCT07602699]RESEARCHA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide [NCT06897475]RESEARCHTranslational Health Research Into Vascular and Neurocognitive Effects of Weight Loss [NCT07592546]RESEARCHTirzepatide in the Treatment of Endometrial Cancer [NCT07605247]RESEARCHA Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan [NCT06635057]RESEARCHA Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) [NCT07165028]NEWSOorja, run by Acceleron veterans, launches to make new fibrosis drugsREGULATORYRFK Jr.: 14 peptides returning to Category 1 — FDA advisory committee July 2026UPDATESemaglutide and tirzepatide compounding ended — shortage resolved Feb/May 2025REGULATORYBPC-157, TB-500, thymosin alpha-1, CJC-1295, ipamorelin: expected Category 1 reclassification pendingFDAFDA advisory committee meetings scheduled: late July 2026RESEARCHA Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature [NCT06382155]RESEARCHMetabolic Effects of Angiotensin-(1-7) [NCT02646475]RESEARCHEvaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder [NCT06651177]RESEARCHMulti-Site Trial of Tirzepatide for Smoking Cessation [NCT07602699]RESEARCHA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide [NCT06897475]RESEARCHTranslational Health Research Into Vascular and Neurocognitive Effects of Weight Loss [NCT07592546]RESEARCHTirzepatide in the Treatment of Endometrial Cancer [NCT07605247]RESEARCHA Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan [NCT06635057]RESEARCHA Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) [NCT07165028]NEWSOorja, run by Acceleron veterans, launches to make new fibrosis drugs

For research purposes only. Full disclaimer →

← Forum

Questions & Help

Ask the community for help

12votes

Is Oxytocin Worth It?

Been researching Oxytocin for a few weeks and I am on the fence about starting. Would love to hear from people who have actually used it. My main concerns: 1. Is the cost justified by the results? 2. How long before you see meaningful effects? 3. Any side effects I should be prepared for? 4. How does it compare to alternatives? I am primarily interested in recovery and general health optimization. Training 4-5 times per week and finding that recovery is becoming a bottleneck. Appreciate any honest feedback. Not looking for hype — just real experiences from real users.

Zion DiazDEMOabout 1 month ago5
12votes

Sermorelin Side Effects — What to Expect?

About to start Sermorelin and I like to be prepared. What side effects should I realistically expect, especially in the first few weeks? I have read the published studies and the side effect profiles seem mild, but I know that clinical trial reporting and real-world experience can differ significantly. What do actual users experience? Specific concerns: - Injection site reactions — how common and how severe? - Any systemic effects in the first week? - Does anything get worse before it gets better? - Any interactions with supplements or other compounds?

Tate JensenDEMOabout 2 months ago5
12votes

Switching to Larazotide From Something Else

Currently using a different protocol for my recovery goals and considering switching to Larazotide. Has anyone made a similar switch and can compare the experiences? What I am hoping Larazotide offers over my current approach: - Better recovery between training sessions - Improved sleep quality - Potentially better joint support I am not expecting miracles but if Larazotide can offer even a marginal improvement in one or two of these areas, it would be worth exploring. Would also love to hear if anyone has experience transitioning between protocols. Is there a washout period needed?

Eden ChenDEMOabout 1 month ago6
12votes

Ozempic — Realistic Expectations?

Trying to calibrate my expectations for Ozempic before starting. I see wildly different claims online ranging from life-changing to barely noticeable. For those who have run a full protocol, what would you say is a realistic expectation for someone in their mid-30s, reasonably fit, training regularly, with no major health issues? I am specifically interested in the magnitude of effects. Like, if my baseline recovery score is 70 out of 100, should I expect it to go to 75? 80? 90? Trying to understand what realistic means in concrete terms.

Maple ArnoldDEMO23 days ago4
12votes

Anyone Tried Melanotan II for Recovery?

Has anyone here used Melanotan II specifically for recovery purposes? I am an athlete dealing with nagging overuse issues and looking for something to support faster recovery between training sessions. What I have read suggests Melanotan II could help, but most reports I find online are either obviously shilling or so vague they are useless. Looking for detailed real-world experiences from people who tracked their recovery metrics. Specific things I am interested in: - How long until recovery benefits became noticeable? - Did the benefits persist after stopping? - Any impact on sleep quality? - Side effects that affected training?

Reign AllenDEMOabout 2 months ago4
10votes

Is KPV Worth It?

Been researching KPV for a few weeks and I am on the fence about starting. Would love to hear from people who have actually used it. My main concerns: 1. Is the cost justified by the results? 2. How long before you see meaningful effects? 3. Any side effects I should be prepared for? 4. How does it compare to alternatives? I am primarily interested in recovery and general health optimization. Training 4-5 times per week and finding that recovery is becoming a bottleneck. Appreciate any honest feedback. Not looking for hype — just real experiences from real users.

Cedar GarciaDEMOabout 1 month ago4
10votes

GLP-1 Agonists Side Effects — What to Expect?

About to start GLP-1 Agonists and I like to be prepared. What side effects should I realistically expect, especially in the first few weeks? I have read the published studies and the side effect profiles seem mild, but I know that clinical trial reporting and real-world experience can differ significantly. What do actual users experience? Specific concerns: - Injection site reactions — how common and how severe? - Any systemic effects in the first week? - Does anything get worse before it gets better? - Any interactions with supplements or other compounds?

Dylan HenryDEMO25 days ago5
10votes

5-Amino-1MQ — Realistic Expectations?

Trying to calibrate my expectations for 5-Amino-1MQ before starting. I see wildly different claims online ranging from life-changing to barely noticeable. For those who have run a full protocol, what would you say is a realistic expectation for someone in their mid-30s, reasonably fit, training regularly, with no major health issues? I am specifically interested in the magnitude of effects. Like, if my baseline recovery score is 70 out of 100, should I expect it to go to 75? 80? 90? Trying to understand what realistic means in concrete terms.

Hayden FreemanDEMOabout 1 month ago6
10votes

Anyone Tried CJC-1295 (with DAC) for Recovery?

Has anyone here used CJC-1295 (with DAC) specifically for recovery purposes? I am an athlete dealing with nagging overuse issues and looking for something to support faster recovery between training sessions. What I have read suggests CJC-1295 (with DAC) could help, but most reports I find online are either obviously shilling or so vague they are useless. Looking for detailed real-world experiences from people who tracked their recovery metrics. Specific things I am interested in: - How long until recovery benefits became noticeable? - Did the benefits persist after stopping? - Any impact on sleep quality? - Side effects that affected training?

Casey BaldwinDEMOabout 2 months ago6
10votes

Switching to AOD-9604 From Something Else

Currently using a different protocol for my recovery goals and considering switching to AOD-9604. Has anyone made a similar switch and can compare the experiences? What I am hoping AOD-9604 offers over my current approach: - Better recovery between training sessions - Improved sleep quality - Potentially better joint support I am not expecting miracles but if AOD-9604 can offer even a marginal improvement in one or two of these areas, it would be worth exploring. Would also love to hear if anyone has experience transitioning between protocols. Is there a washout period needed?

North AustinDEMOabout 2 months ago5
8votes

Switching to GHK-Cu From Something Else

Currently using a different protocol for my recovery goals and considering switching to GHK-Cu. Has anyone made a similar switch and can compare the experiences? What I am hoping GHK-Cu offers over my current approach: - Better recovery between training sessions - Improved sleep quality - Potentially better joint support I am not expecting miracles but if GHK-Cu can offer even a marginal improvement in one or two of these areas, it would be worth exploring. Would also love to hear if anyone has experience transitioning between protocols. Is there a washout period needed?

Reed ColemanDEMOabout 2 months ago4
8votes

FOXO4-DRI — Realistic Expectations?

Trying to calibrate my expectations for FOXO4-DRI before starting. I see wildly different claims online ranging from life-changing to barely noticeable. For those who have run a full protocol, what would you say is a realistic expectation for someone in their mid-30s, reasonably fit, training regularly, with no major health issues? I am specifically interested in the magnitude of effects. Like, if my baseline recovery score is 70 out of 100, should I expect it to go to 75? 80? 90? Trying to understand what realistic means in concrete terms.

Wynn DouglasDEMOabout 1 month ago5
8votes

Anyone Tried Argireline for Recovery?

Has anyone here used Argireline specifically for recovery purposes? I am an athlete dealing with nagging overuse issues and looking for something to support faster recovery between training sessions. What I have read suggests Argireline could help, but most reports I find online are either obviously shilling or so vague they are useless. Looking for detailed real-world experiences from people who tracked their recovery metrics. Specific things I am interested in: - How long until recovery benefits became noticeable? - Did the benefits persist after stopping? - Any impact on sleep quality? - Side effects that affected training?

Chris FieldsDEMO27 days ago6
8votes

Is Tirzepatide Worth It?

Been researching Tirzepatide for a few weeks and I am on the fence about starting. Would love to hear from people who have actually used it. My main concerns: 1. Is the cost justified by the results? 2. How long before you see meaningful effects? 3. Any side effects I should be prepared for? 4. How does it compare to alternatives? I am primarily interested in recovery and general health optimization. Training 4-5 times per week and finding that recovery is becoming a bottleneck. Appreciate any honest feedback. Not looking for hype — just real experiences from real users.

Frankie ColeDEMOabout 2 months ago6
8votes

Dihexa Side Effects — What to Expect?

About to start Dihexa and I like to be prepared. What side effects should I realistically expect, especially in the first few weeks? I have read the published studies and the side effect profiles seem mild, but I know that clinical trial reporting and real-world experience can differ significantly. What do actual users experience? Specific concerns: - Injection site reactions — how common and how severe? - Any systemic effects in the first week? - Does anything get worse before it gets better? - Any interactions with supplements or other compounds?

Eden HensonDEMOabout 1 month ago4
6votes

Switching to Collagen Peptides From Something Else

Currently using a different protocol for my recovery goals and considering switching to Collagen Peptides. Has anyone made a similar switch and can compare the experiences? What I am hoping Collagen Peptides offers over my current approach: - Better recovery between training sessions - Improved sleep quality - Potentially better joint support I am not expecting miracles but if Collagen Peptides can offer even a marginal improvement in one or two of these areas, it would be worth exploring. Would also love to hear if anyone has experience transitioning between protocols. Is there a washout period needed?

Reese HaleDEMO29 days ago4
6votes

Hexarelin — Realistic Expectations?

Trying to calibrate my expectations for Hexarelin before starting. I see wildly different claims online ranging from life-changing to barely noticeable. For those who have run a full protocol, what would you say is a realistic expectation for someone in their mid-30s, reasonably fit, training regularly, with no major health issues? I am specifically interested in the magnitude of effects. Like, if my baseline recovery score is 70 out of 100, should I expect it to go to 75? 80? 90? Trying to understand what realistic means in concrete terms.

Lennox HartDEMOabout 2 months ago4
6votes

MOTS-c Side Effects — What to Expect?

About to start MOTS-c and I like to be prepared. What side effects should I realistically expect, especially in the first few weeks? I have read the published studies and the side effect profiles seem mild, but I know that clinical trial reporting and real-world experience can differ significantly. What do actual users experience? Specific concerns: - Injection site reactions — how common and how severe? - Any systemic effects in the first week? - Does anything get worse before it gets better? - Any interactions with supplements or other compounds?

Kendall VossDEMOabout 2 months ago6
6votes

Is Mounjaro Worth It?

Been researching Mounjaro for a few weeks and I am on the fence about starting. Would love to hear from people who have actually used it. My main concerns: 1. Is the cost justified by the results? 2. How long before you see meaningful effects? 3. Any side effects I should be prepared for? 4. How does it compare to alternatives? I am primarily interested in recovery and general health optimization. Training 4-5 times per week and finding that recovery is becoming a bottleneck. Appreciate any honest feedback. Not looking for hype — just real experiences from real users.

Casey GillDEMO21 days ago9
6votes

Anyone Tried Selank for Recovery?

Has anyone here used Selank specifically for recovery purposes? I am an athlete dealing with nagging overuse issues and looking for something to support faster recovery between training sessions. What I have read suggests Selank could help, but most reports I find online are either obviously shilling or so vague they are useless. Looking for detailed real-world experiences from people who tracked their recovery metrics. Specific things I am interested in: - How long until recovery benefits became noticeable? - Did the benefits persist after stopping? - Any impact on sleep quality? - Side effects that affected training?

Reed HollandDEMOabout 1 month ago5
6votes

Is BPC-157 Worth It?

Been researching BPC-157 for a few weeks and I am on the fence about starting. Would love to hear from people who have actually used it. My main concerns: 1. Is the cost justified by the results? 2. How long before you see meaningful effects? 3. Any side effects I should be prepared for? 4. How does it compare to alternatives? I am primarily interested in recovery and general health optimization. Training 4-5 times per week and finding that recovery is becoming a bottleneck. Appreciate any honest feedback. Not looking for hype — just real experiences from real users.

Dana ChanDEMO2 months ago5
5votes

Semaglutide week 12 check-in

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Casey CarlsonDEMOabout 1 month ago4
5votes

Sermorelin vs CJC-1295 comparison

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Heath GriffinDEMO28 days ago4
5votes

New to peptides - where to start?

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Zara GrimesDEMOabout 1 month ago4
5votes

Traveling with peptides - storage advice

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Lark ConnollyDEMO29 days ago4
5votes

New to peptides - where to start?

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Kit GuthrieDEMO30 days ago4
5votes

Fasting and peptide timing optimization

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Casey HarrisDEMOabout 1 month ago4
5votes

Semaglutide appetite suppression timeline

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Hayden EganDEMOabout 1 month ago4
5votes

Semaglutide appetite suppression timeline

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Ren CassidyDEMO26 days ago4
5votes

Semaglutide week 12 check-in

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Lux FreemanDEMO26 days ago4
5votes

Selank for anxiety - 6 month review

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Phoenix ClarkDEMO27 days ago4
5votes

AOD-9604 fat loss protocol

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Devin GrantDEMO28 days ago4
5votes

Semaglutide week 12 check-in

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Ellis HerreraDEMOabout 1 month ago4
5votes

Selank for anxiety - 6 month review

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Hart JensenDEMOabout 1 month ago4
5votes

AOD-9604 fat loss protocol

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Cedar GarciaDEMOabout 1 month ago4
5votes

Sermorelin vs CJC-1295 comparison

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Emery BoltonDEMOabout 1 month ago4
5votes

Traveling with peptides - storage advice

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

London GlennDEMOabout 1 month ago4
5votes

New to peptides - where to start?

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Aria BridgesDEMOabout 1 month ago4
5votes

Fasting and peptide timing optimization

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Echo FergusonDEMOabout 1 month ago4
5votes

Semaglutide appetite suppression timeline

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Rory ChanDEMOabout 1 month ago4
5votes

Traveling with peptides - storage advice

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Cleo CraneDEMOabout 1 month ago4
5votes

Fasting and peptide timing optimization

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Riley ArmstrongDEMOabout 1 month ago4
5votes

Semaglutide appetite suppression timeline

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Riley ElliotDEMOabout 1 month ago4
5votes

Semaglutide week 12 check-in

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Frankie ColeDEMOabout 1 month ago4
5votes

Selank for anxiety - 6 month review

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Logan CarlsonDEMOabout 1 month ago4
5votes

AOD-9604 fat loss protocol

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Ray CarsonDEMOabout 1 month ago4
5votes

Sermorelin vs CJC-1295 comparison

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Harper ConnollyDEMOabout 1 month ago4
5votes

Traveling with peptides - storage advice

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Sam CrossDEMOabout 1 month ago4
5votes

New to peptides - where to start?

Has anyone else experienced this? I want to make sure my experience is within the normal range. Would appreciate hearing from others who have been through similar protocols.

Darcy CareyDEMOabout 1 month ago4
5votes

Fasting and peptide timing optimization

This is a topic that does not get discussed enough. I think the community would benefit from a thorough discussion about the science behind this, potential risks, and realistic expectations.

Corey GonzalezDEMOabout 2 months ago4